The Combined Regulation of Long Non-coding RNA and RNA-Binding Proteins in Atherosclerosis

被引：11

作者：

Ding, Yuanyuan ^{[1
]}

Yin, Ruihua ^{[1
]}

Zhang, Shuai ^{[1
]}

Xiao, Qi ^{[1
]}

Zhao, Hongqin ^{[1
]}

Pan, Xudong ^{[1
]}

Zhu, Xiaoyan ^{[2
]}

机构：

[1] Qingdao Univ, Dept Neurol, Affiliated Hosp, Qingdao, Peoples R China

[2] Qingdao Univ, Dept Crit Care Med, Affiliated Hosp, Qingdao, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; RNA-binding protein; atherosclerosis; endothelial cells; macrophages; smooth muscle cells; SMOOTH-MUSCLE-CELL; SIGNAL-TRANSDUCTION PATHWAY; VASCULAR ENDOTHELIAL-CELLS; CORONARY-ARTERY-DISEASE; PROMOTES PROLIFERATION; CHOLESTEROL EFFLUX; MACROPHAGE ACTIVATION; INFLAMMATORY RESPONSE; DOWN-REGULATION; UP-REGULATION;

D O I：

10.3389/fcvm.2021.731958

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complex disease closely related to the function of endothelial cells (ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a good understanding of the pathogenesis of atherosclerosis, the underlying molecular mechanisms are still only poorly understood. Therefore, atherosclerosis continues to be an important clinical issue worthy of further research. Recent evidence has shown that long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) can serve as important regulators of cellular function in atherosclerosis. Besides, several studies have shown that lncRNAs are partly dependent on the specific interaction with RBPs to exert their function. This review summarizes the important contributions of lncRNAs and RBPs in atherosclerosis and provides novel and comprehensible interaction models of lncRNAs and RBPs.

引用

页数：15

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