The Combined Regulation of Long Non-coding RNA and RNA-Binding Proteins in Atherosclerosis

被引：11

作者：

Ding, Yuanyuan ^{[1
]}

Yin, Ruihua ^{[1
]}

Zhang, Shuai ^{[1
]}

Xiao, Qi ^{[1
]}

Zhao, Hongqin ^{[1
]}

Pan, Xudong ^{[1
]}

Zhu, Xiaoyan ^{[2
]}

机构：

[1] Qingdao Univ, Dept Neurol, Affiliated Hosp, Qingdao, Peoples R China

[2] Qingdao Univ, Dept Crit Care Med, Affiliated Hosp, Qingdao, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; RNA-binding protein; atherosclerosis; endothelial cells; macrophages; smooth muscle cells; SMOOTH-MUSCLE-CELL; SIGNAL-TRANSDUCTION PATHWAY; VASCULAR ENDOTHELIAL-CELLS; CORONARY-ARTERY-DISEASE; PROMOTES PROLIFERATION; CHOLESTEROL EFFLUX; MACROPHAGE ACTIVATION; INFLAMMATORY RESPONSE; DOWN-REGULATION; UP-REGULATION;

D O I：

10.3389/fcvm.2021.731958

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complex disease closely related to the function of endothelial cells (ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a good understanding of the pathogenesis of atherosclerosis, the underlying molecular mechanisms are still only poorly understood. Therefore, atherosclerosis continues to be an important clinical issue worthy of further research. Recent evidence has shown that long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) can serve as important regulators of cellular function in atherosclerosis. Besides, several studies have shown that lncRNAs are partly dependent on the specific interaction with RBPs to exert their function. This review summarizes the important contributions of lncRNAs and RBPs in atherosclerosis and provides novel and comprehensible interaction models of lncRNAs and RBPs.

引用

页数：15

共 50 条

[1] Regulation of gene expression by RNA-binding proteins and non-coding RNAs
Meister, G.
[J]. FEBS OPEN BIO, 2019, 9 : 4 - 4
[2] RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer
Jonas, Katharina
Calin, George A.
Pichler, Martin
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[3] Interactions between long non-coding RNAs and RNA-binding proteins in cancer
Huang, Handong
Li, Lu
Wen, Kunming
[J]. ONCOLOGY REPORTS, 2021, 46 (06)
[4] Advances in the identification of long non-coding RNA binding proteins
Zhao, Dongqing
Wang, Chunqing
Yan, Shuai
Chen, Ruibing
[J]. ANALYTICAL BIOCHEMISTRY, 2022, 639
[5] RNA binding proteins as modulators of coding and non-coding RNA pathways
Meister, G.
[J]. FEBS JOURNAL, 2016, 283 : 29 - 29
[6] New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer
Yao, Zi-Ting
Yang, Yan-Ming
Sun, Miao-Miao
He, Yan
Liao, Long
Chen, Kui-Sheng
Li, Bin
[J]. CANCER COMMUNICATIONS, 2022, 42 (02) : 117 - 140
[7] Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses
Wang, Yiliang
Wang, Yun
Luo, Weisheng
Song, Xiaowei
Huang, Lianzhou
Xiao, Ji
Jin, Fujun
Ren, Zhe
Wang, Yifei
[J]. THERANOSTICS, 2020, 10 (20): : 9407 - 9424
[8] Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrB
Romeo, T
[J]. MOLECULAR MICROBIOLOGY, 1998, 29 (06) : 1321 - 1330
[9] Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
Iadevaia, Valentina
Gerber, Andre P.
[J]. BIOMOLECULES, 2015, 5 (04) : 2207 - 2222
[10] Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells
Yang, Kai
Liang, Xiaoxiang
Wen, Kunming
[J]. ONCOLOGY REPORTS, 2022, 48 (04)

← 1 2 3 4 5 →