Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia

被引：4
|
作者：
Song, Yang [1 ,2 ]
Fang, Qiuyun [1 ,2 ]
Mi, Yingchang [1 ,2 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Blood Dis, Inst Hematol, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
gene deletion; copy number variation; acute lymphoblastic leukemia; CDKN2A; 2B deletion; IKZF1; deletion; PAX5; prognosis; IKZF1; DELETION; GENOMIC ANALYSIS; ADULT PATIENTS; PRECURSOR; CHILDREN; RISK; ABERRATIONS; THERAPY; PROFILE; GENE;
D O I：
10.3389/fonc.2022.981036
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.
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页数：10
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