Synthesis of furoxan derivatives: DABCO-mediated cascade sulfonylation/cyclization reaction of α-nitro-ketoximes

被引：15
|
作者：
Zhao, Jian-Qiang [1 ,2 ]
Zhou, Ming-Qiang [1 ,2 ]
Zuo, Jian [1 ,2 ]
Xu, Xiao-Ying [1 ]
Zhang, Xiao-Mei [1 ]
Yuan, Wei-Cheng [1 ]
机构：
[1] Chengdu Inst Organ Chem, Chinese Acad Sci, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 10期
基金：
中国国家自然科学基金;
关键词：
alpha-Nitro-ketoximes; Sulfonyl chlorides; Furoxan derivatives; Cascade reaction; DABCO; UNSYMMETRICALLY SUBSTITUTED FUROXANS; N-OXIDE DERIVATIVES; VASODILATOR; CHEMISTRY; SYSTEM;
D O I：
10.1016/j.tet.2015.01.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and efficient method for the synthesis of furoxan derivatives from alpha-nitro-ketoximes and sulfonyl chlorides is reported. A wide variety of furoxan derivatives were smoothly obtained in good yields via a DABCO-mediated cascade sulfonylation/cyclization process under mild conditions. The usefulness of this method was also demonstrated by the conversions of the furoxan products into other promising compounds. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1560 / 1565
页数：6
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