Synthesis of Spirocyclic Compounds by a Ring-Expansion/Cationic Cyclization Cascade Reaction of Chlorosulfate Derivatives

被引：8

作者：

Cala, Lara ^{[1
]}

Rubio-Presa, Ruben ^{[1
]}

Garcia-Pedrero, Olaya ^{[1
]}

Fananas, Francisco J. ^{[1
]}

Rodriguez, Felix ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organometal Enrique Moles, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 10期

关键词：

ODORANT; ALKYNES;

D O I：

10.1021/acs.orglett.0c01101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cascade reaction to prepare spirocarbocyclic compounds from chlorosulfate derivatives has been developed. The process involves an unusual thermal elimination of the chlorosulfate moiety, a ring-expansion reaction, and a subsequent cationic cyclization reaction. Despite the relatively complex skeletal rearrangement, the reaction described here is featured by its operational simplicity, being just a thermal process that does not require additional reagents, catalysts, or additives.

引用

页码：3846 / 3849

页数：4

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