Synthesis and evaluation of the peptide nucleic acids (PNAs) incorporating the 2-amino-6-vinylpurine derivative

被引：0

作者：

Imoto, Shuhei ^{[1
]}

Goto, Makoto ^{[1
]}

Hirohama, Tomoya ^{[1
]}

Nagatsugi, Fumi ^{[1
]}

机构：

[1] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2008年 / 10卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, we established the new strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of the reactivity using these reactive PNAs.

引用

页码：414 / 416

页数：3

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