Solubility enhancement of curcumin, quercetin and rutin by solid dispersion method

Curcumin, quercetin and rutin are pharmaceutical bioactive compounds but their usages are restricted because of low aqueous solubility and wettability which leads to poor dissolution, hence shows low bioavailability. The centre of consideration for this study is to provide solubility enhancement, improved bioavailability and provide a better patient compliance. To improve the hydrophilic and drug delivery characteristics, developed a beta-cyclodextrin and polyvinyl pyrrolidone K30 mediated fixed dose combination drug delivery system via solid dispersion technique. Inclusion complex was prepared as a fixed dose combination of these three bioactive phytoconstituent, obtained from natural sources with different polymers. The formations of inclusion complexes were characterized by Fourier transform infrared, drug content and drug dissolution. Saturation solubility studies also indicated that inclusion complex showed markable increased solubility compared toothers. Physical analysis of solid dispersion, when compared to its apparent compounds by FTIR allows for a change in solid state from the pure crystalline phase to the high-amorphous phase. The drug solubility increased in proportion to the increase in the concentration of polymer. The inclusion complex of PHC-beta-CD prepared by solvent evaporation method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by solvent change precipitation method.