ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE LOVASTATIN DRUG BY SOLID DISPERSION METHOD

被引：0

作者：

Sandeepthi, N. ^{[1
]}

Bai, N. Jhancy Laxmi ^{[1
]}

机构：

[1] Omega Coll Pharm, Dept Pharmaceut, Hyderabad 501301, Telangana, India

来源：

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 02期

关键词：

Hot melt extrusion; Hyperlipidemia; Povidone; Eudragit RL; Eudragit RS; polyethylene glycol (PEG); degree of porosity; Renex; Texafor AIP;

D O I：

10.5281/zenodo.1188902

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle sixe to the absolute mminimum, and hence improving drug wellability solubility increases hence bioavailability may be significantly imprved. They are usually presented as amorphous products, mainly obtained by two major different methods, meaning and solvent evaporation.

引用

页码：1191 / 1206

页数：16

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