Application of organolithium and related reagents in synthesis.: Part 22.: Synthetic strategies based on ortho-aromatic metallation.: A concise regiospecific conversion of benzoic acids into the 4-pyridyl-2H-phthalazin-1-ones.

被引：8

作者：

Brzezinski, JZ ^{[1
]}

Epsztajn, J ^{[1
]}

Bakalarz, AD ^{[1
]}

Lajszczak, A ^{[1
]}

Malinowski, Z ^{[1
]}

机构：

[1] Univ Lodz, Dept Organ Chem, PL-90136 Lodz, Poland

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 03期

关键词：

D O I：

10.1080/00397919908085788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of phthalazin-1-ones 6, 7, 8 via the reaction of 3-hydroxyisoindolin-1-ones 3, 4, 5 with hydrazine hydrate is described. Starting compounds 3, 4, 5 were regiospecifically prepared upon the lithiation (n-BuLi) of the benzanilides 1 and subsequently the reaction of the dilithiated anilides 2 with methyl pyridinecarboxylates.

引用

页码：457 / 473

页数：17

共 15 条

[11] Application of organolithium compounds in organic synthesis .19. Synthetic strategies based on aromatic metallation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids.
Epsztajn, J
Plotka, MW
Grabowska, A
SYNTHETIC COMMUNICATIONS, 1997, 27 (06) : 1075 - 1086
[12] Application of organolithium and related reagents in synthesis .18. Synthetic strategies based on aromatic metallation. A conversion of methyl ortho-pyridoylbenzoates into aza-anthra-5,10-quinones
Epsztajn, J
Jozwiak, A
Krysiak, JK
Lucka, D
TETRAHEDRON, 1996, 52 (33) : 11025 - 11036
[13] Application of organolithium and related reagents in synthesis, part 29 [1]. A concise regiospecific conversion of benzoic acids into 5-(2-carboxyphenyl)-5-phenylpent-2-enoic acids
Bieniek, A
Epsztajn, J
Kulikiewicz, KK
MONATSHEFTE FUR CHEMIE, 2004, 135 (01): : 69 - 77
[14] Application of Organolithium and Related Reagents in Synthesis, Part 29 [1]. A Concise Regiospecific Conversion of Benzoic Acids into 5-(2-Carboxyphenyl)-5-phenylpent-2-enoic Acids
Adam Bieniek
Jan Epsztajn
Krystyna K. Kulikiewicz
Monatshefte für Chemie / Chemical Monthly, 2004, 135 : 69 - 77
[15] Application of organolithium and related reagents in synthesis, part 31: Effective conversion of 3-arylphthalides into 2-(1-aryl-3-oxo-4-alkoxycarbonylbutyl) benzoic acids
Bieniek, Adam
Kulikiewicz, Krystyna K.
Bartczak, Monika M.
SYNTHETIC COMMUNICATIONS, 2006, 36 (21) : 3249 - 3259

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