Tissue Tregs and Maintenance of Tissue Homeostasis

被引：27

作者：

Shao, Qing ^{[1
,2
,3
,4
]}

Gu, Jian ^{[1
,2
,3
,4
]}

Zhou, Jinren ^{[1
,2
,3
,4
]}

Wang, Qi ^{[1
,2
,3
,4
]}

Li, Xiangyu ^{[1
,2
,3
,4
]}

Deng, Zhenhua ^{[1
,2
,3
,4
]}

Lu, Ling ^{[1
,2
,3
,4
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Hepatobiliary Ctr, Nanjing, Peoples R China

[2] Chinese Acad Med Sci, Res Unit Liver Transplantat & Transplant Immunol, Nanjing, Peoples R China

[3] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Jiangsu Canc Hosp, Nanjing, Peoples R China

[4] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

regulatory T cells; tissue Tregs; transcription; immune homeostasis; immune maintenance; REGULATORY T-CELLS; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; PPAR-GAMMA; REG CELLS; DIFFERENTIATION; MEMORY; ACCUMULATION; INFLAMMATION;

D O I：

10.3389/fcell.2021.717903

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in suppressing the immune response and maintaining immune homeostasis. After maturation in the thymus, Tregs leave the thymus and migrate to lymphoid tissues or non-lymphoid tissues. Increasing evidence indicates that Tregs with unique characteristics also have significant effects on non-lymphoid peripheral tissues. Tissue-resident Tregs, also called tissue Tregs, do not recirculate in the blood or lymphatics and attain a unique phenotype distinct from common Tregs in circulation. This review first summarizes the phenotype, function, and cytokine expression of these Tregs in visceral adipose tissue, skin, muscle, and other tissues. Then, how Tregs are generated, home, and are attracted to and remain resident in the tissue are discussed. Finally, how an increased understanding of these tissue Tregs might guide clinical treatment is discussed.

引用

页数：11

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