Inhibition of human 5-HT3A and 5-HT3AB receptors by etomidate, propofol and pentobarbital

被引：13
|
作者：
Ruesch, Dirk
Braun, Hans A.
Wulf, Hinnerk
Schuster, Anika
Raines, Douglas E.
机构：
[1] Univ Hosp Giessen Marburg GmbH, Dept Anaesthesia & Crit Care, D-35033 Marburg, Germany
[2] Univ Marburg, Inst Physiol & Pathophysiol, Div Neuroendocrinol & Neurodynam, Marburg, Germany
[3] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 573卷 / 1-3期
关键词：
etomidate; propofol; pentobarbital; 5-HT3A receptor; 5-HT3AB receptor;
D O I：
10.1016/j.ejphar.2007.07.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The actions of intravenous anaesthetics on 5-HT3AB receptors have not been studied. Using oocyte electrophysiology, the effects of etomidate, propofol, and pentobarbital on human 5-HT3A and 5-HT3AB receptors were studied and compared. Inhibition of peak currents by all three compounds in both receptor subtypes was anaesthetic concentration-dependant and non-competitive. Because the half-maximal inhibitory concentrations for etomidate, propofol and pentobarbital in 5-HT3A and 5-HT3AB receptors were all above their respective anaesthetic concentrations, the results of our study suggest that neither 5-HT3 receptor subtype contributes to the anaesthetic actions of etomidate, propofol or pentobarbital. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：60 / 64
页数：5
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