Synthesis, characterization and antiprotozoal studies of some metal complexes of antimalarial drugs

被引：26
|
作者：
Ajibade, Peter A. [1 ]
Kolawole, Gabriel A. [2 ]
机构：
[1] Univ Ft Hare, Dept Chem, ZA-5700 Alice, South Africa
[2] Univ Zululand, Dept Chem, ZA-3886 Kwa Dlangezwa, South Africa
来源：
TRANSITION METAL CHEMISTRY | 2008年 / 33卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
D O I：
10.1007/s11243-008-9070-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Metal complexes of the antimalarials trimethoprim (TMP), chloroquine (CQ), and pyrimethamine (pyrm) formulated as [Mn(TMP)Cl-2(CH3OH)], [Co(TMP)(2)Cl-2(CH3OH)], [Pt(CQ)(2)Cl-2] and [Cu(pyrm)(2)(CH3COO)(2)] have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, IR and UV-Vis spectroscopy. The IR and electronic spectra are consistent with the proposed geometry for the complexes. The Mn(II) and Pt(II) complexes are four coordinate while the Cu(II) and Co(II) have octahedral geometry. The complexes were tested for in vitro activity against cultures of Trypanosoma cruzi, L. donovani, T. b. rhodesiense and the resistant strains of Plasmodium falciparum to determine their antiprotozoal activities and for their cytotoxicity with L-6 cells. The Pt(II) complex of chloroquine showed enhanced activity against the resistant strain of Plasmodium falciparum.
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页码：493 / 497
页数：5
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