New Approaches to Molecular Diagnostics of Prenatal Pathology

被引:0
|
作者
Pogorelova, T. N. [1 ]
Orlov, V. I. [1 ]
Gunko, V. O. [1 ]
机构
[1] Fed Agcy High Technol Med Care, Rostov Inst Obstet & Pediat, Rostov Na Donu, Russia
关键词
proteomic analysis; difference proteins; amniotic fluid; gestosis; FACTOR-KAPPA-B; AMNIOTIC-FLUID; PREECLAMPSIA; APOPTOSIS; PROTEINS;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Analysis of the spectrum of amniotic fluid proteins in physiological and abnormal pregnancy using proteomic analysis allowed detection of a number of difference proteins, that are absent or, alternatively, appear in gestosis. Among absent proteins, there were NADPH-dependent carbonyl reductase, epidermal fatty acid-binding protein, haptoglobin, calgranulins A and B. In contrast to proteomic spectrum of amniotic fluid in physiological pregnancy, 7 new proteins appear during gestosis, 3 of them were identified: C area of immunoglobulin K-chain, breast cancer metastasis suppressor-1, and protein-1 containing AIG2-like domain. Possible effects of revealed differences in proteomic spectrum on development of main disturbances during gestosis are discussed. Difference proteins detected in amniotic fluid may serve as gestosis markers.
引用
收藏
页码:567 / 570
页数:4
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