Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons

被引：11
|
作者：
Zhang, Li Nan [1 ,2 ]
Su, Su Wen [1 ]
Guo, Fang [1 ]
Guo, Hui Cai [3 ]
Shi, Xiao Lu [1 ]
Li, Wen Ya [1 ]
Liu, Xu [1 ]
Wang, Yong Li [1 ]
机构：
[1] Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China
[2] Hebei Univ Sci & Technol, Dept Pharm, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Peoples R China
[3] Hebei Med Univ, Dept Toxicol, Shijiazhuang 050017, Peoples R China
来源：
BMC NEUROSCIENCE | 2012年 / 13卷
关键词：
LONG-TERM POTENTIATION; RECEPTOR MESSENGER-RNA; PHARMACOLOGICAL ANALYSIS; BODY-TEMPERATURE; 5-HT1A RECEPTORS; VISUAL-CORTEX; SODIUM-PUMP; IN-VITRO; INHIBITION; ATPASE;
D O I：
10.1186/1471-2202-13-10
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. Results: 5-HT (0.1, 1 mM) showed Na+/K+ pump current (Ip) densities of 0.40 +/- 0.04, 0.34 +/- 0.03 pA/pF contrast to 0.63 +/- 0.04 pA/pF of the control of 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition of Ip in a dose-dependent manner in hippocampal CA1 pyramidal neurons. The effect was partly attenuated by ondasetron, a 5-HT3 receptor (5-HT3R) antagonist, not by WAY100635, a 5-HT1AR antagonist, while 1-(3-Chlorophenyl) biguanide hydrochloride (m-CPBG), a 5-HT3R specific agonist, mimicked the effect of 5-HT on Ip. Conclusion: 5-HT inhibits neuronal Na+/K+ pump activity via 5-HT3R in rat hippocampal CA1 pyramidal neurons. This discloses novel mechanisms for the function of 5-HT in learning and memory, which may be a useful target to benefit these patients with cognitive disorder.
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页数：7
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