Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons

被引：11

作者：

Zhang, Li Nan ^{[1
,2
]}

Su, Su Wen ^{[1
]}

Guo, Fang ^{[1
]}

Guo, Hui Cai ^{[3
]}

Shi, Xiao Lu ^{[1
]}

Li, Wen Ya ^{[1
]}

Liu, Xu ^{[1
]}

Wang, Yong Li ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China

[2] Hebei Univ Sci & Technol, Dept Pharm, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Peoples R China

[3] Hebei Med Univ, Dept Toxicol, Shijiazhuang 050017, Peoples R China

来源：

BMC NEUROSCIENCE | 2012年 / 13卷

关键词：

LONG-TERM POTENTIATION; RECEPTOR MESSENGER-RNA; PHARMACOLOGICAL ANALYSIS; BODY-TEMPERATURE; 5-HT1A RECEPTORS; VISUAL-CORTEX; SODIUM-PUMP; IN-VITRO; INHIBITION; ATPASE;

D O I：

10.1186/1471-2202-13-10

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. Results: 5-HT (0.1, 1 mM) showed Na+/K+ pump current (Ip) densities of 0.40 +/- 0.04, 0.34 +/- 0.03 pA/pF contrast to 0.63 +/- 0.04 pA/pF of the control of 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition of Ip in a dose-dependent manner in hippocampal CA1 pyramidal neurons. The effect was partly attenuated by ondasetron, a 5-HT3 receptor (5-HT3R) antagonist, not by WAY100635, a 5-HT1AR antagonist, while 1-(3-Chlorophenyl) biguanide hydrochloride (m-CPBG), a 5-HT3R specific agonist, mimicked the effect of 5-HT on Ip. Conclusion: 5-HT inhibits neuronal Na+/K+ pump activity via 5-HT3R in rat hippocampal CA1 pyramidal neurons. This discloses novel mechanisms for the function of 5-HT in learning and memory, which may be a useful target to benefit these patients with cognitive disorder.

引用

页数：7

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