Nickel-Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and N-Hydroxyphthalimide Esters Enabled by Electrochemical Process

被引：23

作者：

Zhou, Xiao ^{[1
]}

Guo, Lin ^{[1
]}

Zhang, Haoxiang ^{[1
]}

Xia, Raymond Yang ^{[3
]}

Yang, Chao ^{[1
]}

Xia, Wujiong ^{[1
,2
]}

机构：

[1] Harbin Inst Technol Shenzhen, Sch Sci, State Key Lab Urban Water Resource & Environm, Shenzhen 518055, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

[3] Shenzhen Univ, Affiliated Int Sch, Shenzhen 518054, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 09期

基金：

中国国家自然科学基金;

关键词：

electrochemistry; nickel; reductive coupling; acylation; carboxylic acid; KETONE SYNTHESIS; CHLORIDES; ALDEHYDES; REAGENTS; FACILE; AMINES;

D O I：

10.1002/adsc.202200003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A sustainable Ni-catalyzed reductive acylation reaction of carboxylic acids via an electro-chemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N-hydroxyphthalimide (NHP) esters as coupling partners, which exhibits several synthetic advantages, including mild conditions and convenience of amplification (58% yield for 6 mmol scale reaction).

引用

页码：1526 / 1531

页数：6

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