Nickel-Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and N-Hydroxyphthalimide Esters Enabled by Electrochemical Process

被引：23
|
作者：
Zhou, Xiao [1 ]
Guo, Lin [1 ]
Zhang, Haoxiang [1 ]
Xia, Raymond Yang [3 ]
Yang, Chao [1 ]
Xia, Wujiong [1 ,2 ]
机构：
[1] Harbin Inst Technol Shenzhen, Sch Sci, State Key Lab Urban Water Resource & Environm, Shenzhen 518055, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
[3] Shenzhen Univ, Affiliated Int Sch, Shenzhen 518054, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 09期
基金：
中国国家自然科学基金;
关键词：
electrochemistry; nickel; reductive coupling; acylation; carboxylic acid; KETONE SYNTHESIS; CHLORIDES; ALDEHYDES; REAGENTS; FACILE; AMINES;
D O I：
10.1002/adsc.202200003
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A sustainable Ni-catalyzed reductive acylation reaction of carboxylic acids via an electro-chemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N-hydroxyphthalimide (NHP) esters as coupling partners, which exhibits several synthetic advantages, including mild conditions and convenience of amplification (58% yield for 6 mmol scale reaction).
引用
收藏
页码：1526 / 1531
页数：6
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