ANALYSIS OF BLOOD GLUCOSE DYNAMICS IN LIVER TRANSPLANTATION: A MODEL-BASED APPROACH

A safe, effective glycemic control would have beneficial effects on the outcomes of liver transplantation (LT) patients. The model-based validated glycemic control protocol, STAR, is proven for ICU patients. However, the ICING model used for STAR differs in the blood glucose dynamics compared to the LT patients who have no liver for part of the surgery. By localizing the places of extraordinary LT patient's dynamics we can specify modifications for the ICU patient model. These dynamics mainly occur in the: 1) pre-anhepatic phase at the beginning of the surgery; 2) at the portal vein reperfusion; and 3) in the post-anhepatic phase before 500 minutes after the reperfusion.