Targeted laryngeal photodynamic therapy with a balloon diffusing light source

被引：9
|
作者：
Grossman, Craig [1 ]
Zhu, Timothy [1 ]
Finlay, Jarod [1 ]
Dimofte, Andrea [1 ]
Malloy, Kelly [2 ]
O'Malley, Bert, Jr. [2 ]
Weinstein, Gregory [2 ]
Busch, Theresa M. [1 ]
Quon, Harry [1 ,2 ]
机构：
[1] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
来源：
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2010年 / 7卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Photodynamic theraphy; Head and neck pre-malignant lesions; ALA; Levulan (R); Protoporphyrin IX; Balloon catheter;
D O I：
10.1016/j.pdpdt.2010.06.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：158 / 161
页数：4
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