Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury

被引:39
|
作者
Solling, C. [1 ,2 ]
Christensen, A. T. [1 ,2 ]
Krag, S. [3 ]
Frokiaer, J. [2 ,4 ]
Wogensen, L. [2 ,5 ]
Krog, J. [1 ,2 ]
Tonnesen, E. K. [1 ,2 ]
机构
[1] Aarhus Univ Hosp, Dept Anesthesiol & Intens Care Med, DK-8000 Aarhus C, Denmark
[2] Aarhus Univ, Inst Clin Med, Aarhus, Denmark
[3] Aarhus Univ Hosp, Dept Pathol, DK-8000 Aarhus, Denmark
[4] Aarhus Univ Hosp, Dept Clin Physiol, DK-8000 Aarhus, Denmark
[5] Aarhus Univ Hosp, Res Lab Biochem Pathol, DK-8000 Aarhus, Denmark
关键词
ACUTE-RENAL-FAILURE; CELL-DEATH; PROTECTS; KIDNEY; ISCHEMIA/REPERFUSION; EXPRESSION; MODEL;
D O I
10.1111/j.1399-6576.2010.02369.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background Erythropoietin (EPO) is a cytokine with organ-protective properties. We hypothesized that EPO could attenuate acute renal dysfunction and inflammation in a porcine model of ischemia-reperfusion (IR). Furthermore, we aimed to characterize the impact of EPO on systemic and renal hemodynamics, and renal oxygen consumption. Methods Twenty-four pigs were randomly assigned to three groups: (1) EPO (5000 IU/kg) administered intravenously before IR (n=9), (2) placebo administered before IR (n=9), or (3) sham group, anesthetized and operated on only (n=6). IR was induced by clamping the left renal artery for 45 min. Hemodynamics and renal blood flow (RBF) were analyzed continuously. Glomerular filtration rate (GFR), renal oxygen consumption, and plasma cytokines (IL-1 beta, IL-6, IL-8, IL-10, and TNF-alpha) were analyzed hourly. Renal biopsies were analyzed for cytokine content and apoptosis. Results GFR was higher during reperfusion in the EPO group than in the placebo group (P < 0.01). No differences between the IR groups were found in hemodynamics, RBF, oxygen consumption, or renal apoptosis. The levels of TNF-alpha in the plasma (P=0.036) and the levels of TNF-alpha and IL-10 in the renal cortex (P=0.04 and P=0.01, respectively) were lower in the EPO group compared with the sham group. Conclusion EPO attenuated the renal dysfunction as estimated as GFR. This effect was not related to changes in the hemodynamics. The immunomodulatory effects of EPO were manifested as decreased levels of TNF-alpha and IL-10 in renal biopsies and TNF-alpha levels in plasma.
引用
收藏
页码:185 / 195
页数:11
相关论文
共 50 条
  • [31] Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury
    Rancan, Lisa
    Simon, Carlos
    Marchal-Duval, Emmeline
    Casanova, Javier
    Paredes, Sergio Damian
    Calvo, Alberto
    Garcia, Cruz
    Rincon, David
    Turrero, Agustn
    Garutti, Ignacio
    Vara, Elena
    ANESTHESIA AND ANALGESIA, 2016, 123 (06): : 1437 - 1447
  • [32] Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus
    Krishnadasan, B
    Naidu, B
    Rosengart, M
    Farr, AL
    Barnes, A
    Verrier, ED
    Mulligan, MS
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2002, 123 (04): : 756 - 767
  • [33] Dexmedetomidine Administration before, but Not after, Ischemia Attenuates Intestinal Injury Induced by Intestinal Ischemia-Reperfusion in Rats
    Zhang, Xu-Yu
    Liu, Zi-Meng
    Wen, Shi-Hong
    Li, Yun-Sheng
    Li, Yi
    Yao, Xi
    Huang, Wen-Qi
    Liu, Ke-Xuan
    ANESTHESIOLOGY, 2012, 116 (05) : 1035 - 1046
  • [34] Liver repair and regeneration after ischemia-reperfusion injury is associated with prolonged fibrosis
    Konishi, Takanori
    Schuster, Rebecca M.
    Lentsch, Alex R.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2019, 316 (03): : G323 - G331
  • [35] Effect of short-term administration of prostaglandin E1 on viability after ischemia/reperfusion injury with extended hepatectomy in cirrhotic rat liver
    Hossain, MA
    Izuishi, K
    Maeta, H
    WORLD JOURNAL OF SURGERY, 2003, 27 (10) : 1155 - 1160
  • [36] Effect of Short-term Administration of Prostaglandin E1 on Viability after Ischemia/Reperfusion Injury with Extended Hepatectomy in Cirrhotic Rat Liver
    Mohammad Akram Hossain
    Kunihiko Izuishi
    Hajime Maeta
    World Journal of Surgery, 2003, 27 : 1155 - 1160
  • [37] Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury
    Wright, GL
    Hanlon, P
    Amin, K
    Steenbergen, C
    Murphy, E
    Arcasoy, MO
    FASEB JOURNAL, 2004, 18 (06): : 1031 - +
  • [38] Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants
    Ko, KM
    Mak, DHF
    Poon, MKT
    Yiu, HY
    JAPANESE JOURNAL OF PHARMACOLOGY, 2001, 85 (04): : 435 - 442
  • [39] Short-Term Inhalation of Nitric Oxide Inhibits Activations of Toll-Like Receptor 2 and 4 in the Lung after Ischemia-Reperfusion Injury in Mice
    郑志坤
    王建军
    胡辉
    江科
    聂君
    张俊
    郭辉
    乔新伟
    李劲松
    Current Medical Science, 2013, (02) : 219 - 223
  • [40] Short-term inhalation of nitric oxide inhibits activations of toll-like receptor 2 and 4 in the lung after ischemia-reperfusion injury in mice
    Zhi-kun Zheng
    Jian-jun Wang
    Hui Hu
    Ke Jiang
    Jun Nie
    Jun Zhang
    Hui Guo
    Xin-wei Qiao
    Jin-song Li
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2013, 33 : 219 - 223