Novel application of HKUST-1 metal-organic framework as antifungal: Biological tests and physicochemical characterizations

被引：76
|
作者：
Chiericatti, Carolina [2 ]
Carlos Basilico, Juan [2 ]
Zapata Basilico, Maria L. [2 ]
Manuel Zamaro, Juan [1 ]
机构：
[1] UNL CONICET, INCAPE FIQ, Inst Invest Catalisis & Petroquim, RA-3000 Santa Fe, Argentina
[2] Univ Natl Litoral, Fac Ingn Quim, Catedra Microbiol, RA-3000 Santa Fe, Argentina
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2012年 / 162卷
关键词：
Metal-organic framework; HKUST-1; Anti fungal activity; Copper release; ANTIMICROBIAL ACTIVITY; COPPER NANOPARTICLES; COMPLEXES; SILVER;
D O I：
10.1016/j.micromeso.2012.06.012
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The HKUST-1 metal-organic framework (MOF) was successfully applied as a biocidal material against representative yeast and mold. The synthesized MOF showed a strong antifungal effect against Saccharomyces cerevisiae for which the growth was completely inhibited, whereas the growth of Geotrichum candidum was reduced from 6.16 to 1.29 CFU mL(-1). The antifungal action was related to copper ions released into the culture medium due to a progressive degradation of the crystalline structure of the material that involved the formation of surface extra-framework Cu(I). This study shows the potential of using copper-based metal-organic frameworks for a controlled release of biologically active copper ions. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：60 / 63
页数：4
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