Mechanism for gastric cancer development by Helicobacter pylori infection

被引：67
|
作者：
Chiba, Tsutomu [1 ]
Marusawa, Hiroyuki [1 ]
Seno, Hiroshi [1 ]
Watanabe, Norihiko [1 ]
机构：
[1] Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Kyoto 6068507, Japan
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2008年 / 23卷 / 08期
关键词：
gastric epithelial cells; gastric cancer; Helicobacter pylori;
D O I：
10.1111/j.1440-1746.2008.05472.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori (H. pylori) infection plays a crucial role in the development of gastric cancer. There are two major pathways for the development of gastric cancer by H. pylori infection: the indirect action of H. pylori on gastric epithelial cells through inflammation, and the direct action of the bacteria on epithelial cells through the induction of protein modulation and gene mutation. Both pathways work together to promote gastric carcinogenesis.
引用
收藏
页码：1175 / 1181
页数：7
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