Mechanism for gastric cancer development by Helicobacter pylori infection

被引：67
|
作者：
Chiba, Tsutomu [1 ]
Marusawa, Hiroyuki [1 ]
Seno, Hiroshi [1 ]
Watanabe, Norihiko [1 ]
机构：
[1] Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Kyoto 6068507, Japan
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2008年 / 23卷 / 08期
关键词：
gastric epithelial cells; gastric cancer; Helicobacter pylori;
D O I：
10.1111/j.1440-1746.2008.05472.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori (H. pylori) infection plays a crucial role in the development of gastric cancer. There are two major pathways for the development of gastric cancer by H. pylori infection: the indirect action of H. pylori on gastric epithelial cells through inflammation, and the direct action of the bacteria on epithelial cells through the induction of protein modulation and gene mutation. Both pathways work together to promote gastric carcinogenesis.
引用
收藏
页码：1175 / 1181
页数：7
相关论文
共 50 条
  • [1] Persistent infection with Helicobacter pylori and the development of gastric cancer
    Normark, S
    Nilsson, C
    Normark, BH
    Hornef, MW
    [J]. ADVANCES IN CANCER RESEARCH, VOL 90, 2003, 90 : 63 - 89
  • [2] Mechanisms of gastric cancer development by Helicobacter pylori infection
    Chiba, Tsutomu
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 : 27 - 27
  • [3] Helicobacter pylori infection and the development of gastric cancer.
    Uemura, N
    Okamoto, S
    Yamamoto, S
    Matsumura, N
    Yamaguchi, S
    Yamakido, M
    Taniyama, K
    Sasaki, N
    Schlemper, RJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (11): : 784 - 789
  • [4] Relevance of Helicobacter pylori infection in the development of gastric cancer
    Bartram, HP
    [J]. TIERARZTLICHE PRAXIS AUSGABE KLEINTIERE HEIMTIERE, 1998, 26 (03): : 154 - 159
  • [5] Helicobacter pylori infection and the development of gastric cancer -: Reply
    Uemura, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (01): : 66 - 67
  • [6] Helicobacter pylori infection and development of gastric cancer in Korea
    Kim, Nayoung
    Park, Ran Young
    Clio, Sung-Il
    Lim, Seon Hee
    Lee, Kye Heui
    Lee, Wooseung
    Kang, Hyung Min
    Lee, Hye Seung
    Jung, Hyun Chae
    Song, In Sung
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 2008, 42 (05) : 448 - 454
  • [7] Development of gastric cancer associated with Helicobacter pylori infection
    Sugiyama, T
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2004, 54 (Suppl 1) : S12 - S20
  • [8] Effect of Helicobacter pylori infection on gastric cancer development
    Ribeiro, Marcelo L.
    Bartchewsky, Waldemar, Jr.
    Martini, Mariana R.
    Alvarez, Marisa C.
    Salvadori, Daisy M.
    Ladeira, Marcelo S.
    Pedrazzoli, Jose, Jr.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 : S171 - S171
  • [9] Development of gastric cancer associated with Helicobacter pylori infection
    Toshiro Sugiyama
    [J]. Cancer Chemotherapy and Pharmacology, 2004, 54 : S12 - S20
  • [10] Helicobacter pylori infection and gastric cancer
    Matysiak-Budnik, T
    Mégraud, F
    [J]. EUROPEAN JOURNAL OF CANCER, 2006, 42 (06) : 708 - 716
12345