Biomimetic fabrication and characterization of collagen/strontium hydroxyapatite nanocomposite

被引：18
|
作者：
Qi, Yipin [1 ]
Mai, Sui [1 ]
Ye, Zhou [2 ]
Aparicio, Conrado [2 ]
机构：
[1] Sun Yat Sen Univ, Hosp Stomatol, Dept Operat Dent & Endodont, Guangdong Key Lab Stomatol, Guangzhou 510000, Peoples R China
[2] Univ Minnesota, MDRCBB Minnesota Dent Res Ctr Biomat & Biomech, Minneapolis, MN 55455 USA
来源：
MATERIALS LETTERS | 2020年 / 274卷
基金：
中国国家自然科学基金;
关键词：
Type I collagen; Strontium hydroxyapatite; Nanocomposites; Nanocrystals; Biomimetic; STRONTIUM; MINERALIZATION; COLLAGEN;
D O I：
10.1016/j.matlet.2020.127982
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Strontium-releasing bioactive materials have attracted considerable attention for patients with osteoporotic bone defects due to its ability to stimulate bone formation and decrease bone resorption. In the present study, type I collagen/strontium hydroxyapatite nanocomposite (cSrHA) was fabricated via a non-classical biomimetic mineralization pathway. Mineralized collagen fibrils with nanosized SrHA embedded in intrafibrillar interstices were obtained using poly(acrylic acid) as a biomimetic mineralizing director. The resultant nanocomposite was characterized by SEM, TEM, EDS, ATR-FTIR, XRD and TGA. cSrHA displayed morphologies, nanostructures and characteristics similar to those of natural hard tissue and calcium hydroxyapatite-mineralized collagen (cCaHA), indicating its potential value as a biofunctional material for bone engineering.
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页数：4
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