Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide

被引：29
|
作者：
Ayaz, Basak Donertas [1 ,2 ]
Zubcevic, Jasenka [1 ]
机构：
[1] Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA
[2] Univ Eskisehir Osmangazi, Coll Med, Dept Pharmacol, Eskisehir, Turkey
来源：
PHARMACOLOGICAL RESEARCH | 2020年 / 153卷
基金：
美国国家卫生研究院;
关键词：
Hypertension; Neuroinflammation; Gut microbiota; Hydrogen sulfide; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ROSTRAL VENTROLATERAL MEDULLA; SYMPATHETIC AFFERENT REFLEX; RENIN-ANGIOTENSIN SYSTEM; II-INDUCED HYPERTENSION; CYSTATHIONINE-BETA-SYNTHASE; SULFATE-REDUCING BACTERIA; METHIONINE-SUPPLEMENTED DIET; ATTENUATES OXIDATIVE STRESS; SALT-INDUCED HYPERTENSION;
D O I：
10.1016/j.phrs.2020.104677
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Inflammation and gut dysbiosis are hallmarks of hypertension (HTN). Hydrogen sulfide (H2S) is an important freely diffusing molecule that modulates the function of neural, cardiovascular and immune systems, and circulating levels of H2S are reduced in animals and humans with HTN. While most research to date has focused on H2S produced endogenously by the host, H2S is also produced by the gut bacteria and may affect the host homeostasis. Here, we review an association between neuroinflammation and gut dysbiosis in HTN, with special emphasis on a potential role of H2S in this interplay.
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页数：13
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