The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer

被引：10
|
作者：
Li, Juan [1 ,2 ]
Liu, Jie [1 ,2 ]
Li, Pingping [1 ,2 ]
Zhou, Can [3 ]
Liu, Peijun [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Ctr Translat Med, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Key Lab Tumor Precis Med Shaanxi Prov, Xian 710061, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Surg Oncol, Xian 710061, Shaanxi, Peoples R China
来源：
EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 243卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Breast cancer stem cells; chemoresistance; WW domain-containing oxidoreductase; TUMOR-SUPPRESSOR PROTEIN; CELLS; ASSOCIATION; EXPRESSION; TUMORIGENICITY; RESISTANCE; SUBTYPES; GENE;
D O I：
10.1177/1535370218806455
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
WW domain-containing oxidoreductase (WWOX), an important tumor suppressor, is essential for regulating cell proliferation and apoptosis. Our study demonstrates that low level of WWOX is associated with the triple-negative subtype of breast cancer (TNBC), which has higher stem cell phenotype and chemoresistance. We evaluated the role of WWOX in regulation of breast cancer stem cells (BCSC) phenotype and chemoresistance. Our results showed that knockdown of WWOX increases the stemness of breast cancer cells. Meanwhile, downregulation of WWOX induces the epithelial-mesenchymal transition (EMT) and chemoresistance of breast cancer cell lines. Our findings revealed the role of the WWOX in the regulation of the BCSC population and chemotherapeutic sensitivity and may provide insights for the development of more effective therapies targeting cancer stem cells in breast cancer.
引用
收藏
页码：1066 / 1073
页数：8
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