Metaplasia in the Stomach-Precursor of Gastric Cancer?

被引：74
|
作者：
Kinoshita, Hiroto [1 ]
Hayakawa, Yoku [1 ]
Koike, Kazuhiko [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期
关键词：
gastric cancer; intestinal metaplasia; Spasmolytic polypeptide expressing metaplasia (SPEM); Helicobacter pylori; stem cells; lineage tracing; HELICOBACTER-PYLORI CAGA; NF-KAPPA-B; POLYPEPTIDE-EXPRESSING METAPLASIA; STEM-CELL NICHE; INTESTINAL METAPLASIA; EPITHELIAL-CELLS; TRANSGENIC MICE; CHIEF CELLS; MOUSE STOMACH; IV SECRETION;
D O I：
10.3390/ijms18102063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by H. pylori infection.
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页数：16
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