Metaplasia in the Stomach-Precursor of Gastric Cancer?

被引：74

作者：

Kinoshita, Hiroto ^{[1
]}

Hayakawa, Yoku ^{[1
]}

Koike, Kazuhiko ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期

关键词：

gastric cancer; intestinal metaplasia; Spasmolytic polypeptide expressing metaplasia (SPEM); Helicobacter pylori; stem cells; lineage tracing; HELICOBACTER-PYLORI CAGA; NF-KAPPA-B; POLYPEPTIDE-EXPRESSING METAPLASIA; STEM-CELL NICHE; INTESTINAL METAPLASIA; EPITHELIAL-CELLS; TRANSGENIC MICE; CHIEF CELLS; MOUSE STOMACH; IV SECRETION;

D O I：

10.3390/ijms18102063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by H. pylori infection.

引用

页数：16

共 50 条

[1] Novel treatment for gastric intestinal metaplasia, a precursor to cancer
Lam, Shiu Kum
Lau, George
JGH OPEN, 2020, 4 (04): : 569 - 573
[2] Osseous Metaplasia in a Gastric Adenoma of the Stomach
Tawfik, Ossama
Jonnalagadda, Sreenivasa
Siddiqui, Gulnaz
Downing, Robert P.
McNally, Megan
ACG CASE REPORTS JOURNAL, 2022, 9 (04)
[3] Intestinal Metaplasia of the Stomach Is Associated with an Increased Risk of Gastric Cancer in a Western Population
Bleibel, Wissam
Frye, Jeanetta
Gomez, Justin
Sauer, Bryan
Shami, Vanessa
Wang, Andrew
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 : S48 - S48
[4] A CANCER CODON IN INTESTINAL METAPLASIA OF THE STOMACH
DEUTSCH, E
WALKER, J
DICKERSON, WJ
GASTROINTESTINAL ENDOSCOPY, 1984, 30 (02) : 132 - 132
[5] Metaplasia in the Stomach Arises From Gastric Chief Cells
Mills, Jason C.
Goldenring, James R.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2017, 4 (01): : 85 - 88
[6] OCCURRENCE OF INTESTINAL METAPLASIA OF THE STOMACH IN THAI PATIENTS WITH GASTRITIS, BENIGN ULCER, AND GASTRIC-CANCER
PONGCHAIRERKS, P
CHALERMSANYAKORN, P
TANJAPATKUL, M
JOURNAL OF SURGICAL ONCOLOGY, 1990, 43 (02) : 101 - 105
[7] INTESTINAL METAPLASIA OF GASTRIC EPITHELIUM IN CHINESE AND AMERICANS AND ITS SIGNIFICANCE AS A PRECANCEROUS LESION OF STOMACH CANCER
林慧芝
张荫昌
Pelayo Correa
Vivien Chen
中国医科大学学报, 1988, (S2) : 23 - 29
[8] Gastric cancer and intestinal metaplasia
Bronner, MP
HUMAN PATHOLOGY, 1999, 30 (07) : 733 - 733
[9] Cellular Plasticity in the Stomach: Insights Into the Cellular Origin of Gastric Metaplasia
Hibdon, Elise S.
Samuelson, Linda C.
GASTROENTEROLOGY, 2018, 154 (04) : 801 - 803
[10] HIGH INCIDENCE OF MICROSCOPIC GASTRIC INTESTINAL METAPLASIA IN PATIENTS WITH ENDOSCOPICALLY NORMAL STOMACH IN A LOW PREVALENCE GASTRIC CANCER REGION
Alakkari, A.
O'Connor, A.
O'Morain, C.
HELICOBACTER, 2011, 16 : 95 - 95

← 1 2 3 4 5 →