Hydroxymethylpyridine catalysts for the enantioselective alkynylation of aldehydes

被引：21
|
作者：
Liebehentschel, Sabrina [1 ]
Cvengros, Jan [1 ]
Jacobi von Wangelin, Axel [1 ]
机构：
[1] Univ Cologne, Dept Organ Chem, D-50939 Cologne, Germany
来源：
SYNLETT | 2007年 / 16期
关键词：
alkynes; propargylic alcohols; pyridines; asymmetric; catalysis; zinc;
D O I：
10.1055/s-2007-986630
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral 2-hydroxymethylpyridines based on fenchol and menthol were evaluated as catalysts for the enantioselective addition of terminal alkynes to aldehydes. With one of the fenchol-based ligands, the operationally simple protocol gave propargylic alcohols with excellent yields and up to 85% ee for various aldehyde and alkyne derivatives.
引用
收藏
页码：2574 / 2578
页数：5
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