Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

被引：27
|
作者：
Bellier, B [1 ]
Da Nascimento, S [1 ]
Meudal, H [1 ]
Gincel, E [1 ]
Roques, BP [1 ]
Garbay, C [1 ]
机构：
[1] UFR Sci Pharmaceut & Biol, CNRS URA D1500, INSERM U266, Dept Pharmacochim Mol & Struct, F-75270 Paris 06, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期
关键词：
cholecystokinin; peptoids; antagonists;
D O I：
10.1016/S0960-894X(98)00231-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1419 / 1424
页数：6
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