Clinical Implications of Primary Cilia in Skin Cancer

被引：8

作者：

Choudhury, Abrar ^{[1
,3
,4
]}

Neumann, Neil M. ^{[1
]}

Raleigh, David R. ^{[3
,4
]}

Lang, Ursula E. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94140 USA

[2] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA

来源：

DERMATOLOGY AND THERAPY | 2020年 / 10卷 / 02期

关键词：

Basal cell carcinoma; Diagnostic tool; Hedgehog; Melanoma; Primary cilia; Sonidegib; Vismodegib; BASAL-CELL CARCINOMA; TUMOR-SUPPRESSOR GENE; HEDGEHOG PATHWAY; SONIC-HEDGEHOG; HAIR FOLLICLE; MELANOCYTIC NEOPLASMS; GENOMIC ANALYSIS; MELANOMA-CELLS; HUMAN HOMOLOG; EXPRESSION;

D O I：

10.1007/s13555-020-00355-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care.

引用

页码：233 / 248

页数：16

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