A facile synthesis of 1,1-disubstituted isoindoline derivatives by intramolecular iodoamination of 2-vinylbenzylamine derivatives

被引：8

作者：

Kobayashi, Kazuhiro ^{[1
]}

Kondo, Shizuka ^{[1
]}

Hashimoto, Kenichi ^{[1
]}

Fukamachi, Shuhei ^{[1
]}

Morikawa, Osamu ^{[1
]}

Konishi, Hisatoshi ^{[1
]}

机构：

[1] Tottori Univ, Fac Engn, Dept Mat Sci, Tottori 6808552, Japan

来源：

HETEROCYCLES | 2007年 / 71卷 / 08期

关键词：

iodine; iodoamination; isoindoline; sodium thiolate; 2-vinylbenzylamine;

D O I：

10.3987/COM-07-11072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intramolecular iodoamination of N-(2-vinylbenzyl)acetamide derivatives, derived from cc-substituted 2-vinylbenzonitriles in two steps, afforded the corresponcling 2-acetyl-1-iodomethylisoindoline derivatives, which were transformed into the 1-methyl or 1-Sulfenylmethyl derivatives by tributyltin hydride reduction or substitution by sodium thiolates, respectively, in reasonable yields.

引用

页码：1827 / 1835

页数：9

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