Dopamine DRD2/Cys311 is not associated with chronic schizophrenia

被引：0

作者：

Crawford, F ^{[1
]}

Hoyne, J ^{[1
]}

Cai, XG ^{[1
]}

Osborne, A ^{[1
]}

Poston, D ^{[1
]}

Zaglul, J ^{[1
]}

Dajani, N ^{[1
]}

Walsh, S ^{[1
]}

Bradley, R ^{[1
]}

Solomon, R ^{[1
]}

Mullan, M ^{[1
]}

机构：

[1] G PIERCE WOOD MEM HOSP,MED EXECUT DEPT,ARCADIA,FL

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1996年 / 67卷 / 05期

关键词：

schizophrenia; genetic association; DRD2; receptor; Ser/Cys; 311; variant;

D O I：

10.1002/(SICI)1096-8628(19960920)67:5<483::AID-AJMG8>3.0.CO;2-L

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A mutation in the DRD2 receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations, The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional, We report the results of screening US Caucasian schizophrenic and nonschizophrenic populations, We detected the occurrence of the DRD2 Cys311 variant in both schizophrenics and controls, Our data demonstrates no significant difference between the frequency of Cys311 in Caucasian schizophrenic and non-schizophrenic populations, indicating no association with schizophrenia. (C) 1996 Wiley-Liss, Inc.

引用

页码：483 / 484

页数：2

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