sp3 C-H Bond Activation with Ruthenium(II) Catalysts and C(3)-Alkylation of Cyclic Amines

被引：159

作者：

Sundararaju, Basker ^{[1
]}

Achard, Mathieu ^{[1
]}

Sharma, Gangavaram V. M. ^{[2
]}

Bruneau, Christian ^{[1
]}

机构：

[1] Univ Rennes, CNRS UMR6226, F-35042 Rennes, France

[2] Indian Inst Chem Technol CSIR, Discovery Lab, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 27期

关键词：

HYDROGEN-TRANSFER REACTIONS; TERTIARY-AMINES; OXIDATIVE CYANATION; BORROWING HYDROGEN; SODIUM-CYANIDE; NITROGEN ATOM; DEHYDROGENATION; COMPLEXES; ADJACENT; ALKENES;

D O I：

10.1021/ja203875d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.

引用

页码：10340 / 10343

页数：4

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