Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides

被引：102
|
作者：
Huang, Yuan [1 ]
Smith, Kevin B. [1 ]
Brown, M. Kevin [1 ]
机构：
[1] Indiana Univ, Dept Chem, 800 E Kirkwood Ave, Bloomington, IN 47401 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 43期
基金：
美国国家卫生研究院;
关键词：
acid chlorides; alkenes; boron; copper; homogeneous catalysis; KETONE SYNTHESIS; ENANTIOSELECTIVE ARYLBORATION; ACYL CHLORIDES; CARBOBORATION; DERIVATIVES; BORYLATION; ALDEHYDES; REAGENTS; ALLENES; ESTERS;
D O I：
10.1002/anie.201707323
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the copper-catalyzed borylacylation of activated alkenes is presented. The reaction involves borylcupration of the alkene, followed by capture of the generated alkyl-copper intermediate with an acid chloride. The reactions operated with low catalyst loading and generally occurre within 15min at room temperature for a range of activated alkenes. In the case of vinyl arenes, enantioselective borylacylation was possible.
引用
收藏
页码：13314 / 13318
页数：5
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