The Effect of Proton Pump Inhibitors on Barrett's Esophagus

被引：19
|
作者：
Dunbar, Kerry B. [1 ]
Souza, Rhonda F. [1 ]
Spechler, Stuart J. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Div Gastroenterol & Hepatol, Dept Med, Dallas VA Med Ctr, Dallas, TX 75231 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2015年 / 44卷 / 02期
关键词：
Barrett's esophagus; Proton pump inhibitor; Dysplasia; Esophageal cancer; Gastroesophageal reflux disease; GASTROESOPHAGEAL-REFLUX DISEASE; ACID REFLUX; DNA-DAMAGE; KAPPA-B; ADENOCARCINOMA; PROLIFERATION; GASTRIN; DYSPLASIA; RISK; PH;
D O I：
10.1016/j.gtc.2015.02.010
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.
引用
收藏
页码：415 / +
页数：11
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