Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-a]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate

被引：7
|
作者：
Gein, V. L. [1 ]
Mishunin, V. V. [1 ]
Tsyplyakova, E. P. [2 ]
Vakhrin, M. I. [1 ]
Slepukhin, P. A. [3 ]
机构：
[1] Fed Hlth & Social Dev Agcy, Perm State Pharmaceut Acad, Perm 614990, Russia
[2] Russian State Univ Trade & Econ, Perm Inst Branch, Perm 614070, Russia
[3] Russian Acad Sci, Postovskii Inst Organ Synth, Ural Div, Ekaterinburg 620219, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 47卷 / 07期
关键词：
Aromatic Aldehyde; Hydrazine Hydrate; Ylate; Pyridazin; Ketone Carbonyl Group;
D O I：
10.1134/S1070428011070189
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fusion of methyl 4-(2-thienyl)-2,4-dioxobutanoate with 1H-tetrazol-5-amine monohydrate and aromatic aldehyde gave methyl 7-aryl-6-(2-thenoyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates which reacted with an equimolar amount of hydrazine hydrate at 180-190A degrees C under solvent-free conditions to produce 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1',5': 1,2]pyrimido[4,5-d]pyridazin-5(6H)-ones.
引用
收藏
页码：1077 / 1082
页数：6
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