Score tests for epistasis models on quantitative traits using general pedigree data

被引：4
|
作者：
Wang, K [1 ]
机构：
[1] Univ Iowa, Coll Publ Hlth, Dept Biostat, Div Stat Genet, Iowa City, IA 52242 USA
来源：
GENETIC EPIDEMIOLOGY | 2003年 / 25卷 / 04期
关键词：
QTL; epistasis; variance component; likelihood ratio statistic; score statistic;
D O I：
10.1002/gepi.10266
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Efficient score tests for a two-locus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalency to their respective likelihood ratio tests and efficiency in computation. The finite-sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：314 / 326
页数：13
相关论文
共 50 条
  • [41] Robust Association Tests Under Different Genetic Models, Allowing for Binary or Quantitative Traits and Covariates
    Hon-Cheong So
    Pak C. Sham
    [J]. Behavior Genetics, 2011, 41 : 768 - 775
  • [42] On the Efficiency of Score Tests for Homogeneity in Two-Component Parametric Models for Discrete Data
    Todem, David
    Hsu, Wei-Wen
    Kim, KyungMann
    [J]. BIOMETRICS, 2012, 68 (03) : 975 - 982
  • [43] ESTIMATING SELECTION ON QUANTITATIVE TRAITS USING CAPTURE-RECAPTURE DATA
    KINGSOLVER, JG
    SMITH, SG
    [J]. EVOLUTION, 1995, 49 (02) : 384 - 388
  • [44] Asymptotic equivalence between two score tests for haplotype-specific risk in general linear models
    Xie, RR
    Stram, DO
    [J]. GENETIC EPIDEMIOLOGY, 2005, 29 (02) : 166 - 170
  • [45] Detection Tests Using Sparse Models, With Application to Hyperspectral Data
    Paris, Silvia
    Mary, David
    Ferrari, Andre
    [J]. IEEE TRANSACTIONS ON SIGNAL PROCESSING, 2013, 61 (06) : 1481 - 1494
  • [46] Getting the most from your data: Comparing analyses using qualitative traits and related quantitative traits
    Sabourin, Jeremy A.
    Sorant, Alexa J. M.
    Wilson, Alexander F.
    [J]. GENETIC EPIDEMIOLOGY, 2015, 39 (07) : 577 - 577
  • [47] SCORE TESTS FOR ZERO COVARIANCES IN RECURSIVE LINEAR-MODELS FOR GROUPED OR CENSORED-DATA
    CHESHER, A
    [J]. JOURNAL OF ECONOMETRICS, 1985, 28 (03) : 291 - 305
  • [48] Statistical tests for comparison of quantitative and qualitative models developed with near infrared spectral data
    Roggo, Y
    Duponchel, L
    Ruckebusch, C
    Huvenne, JP
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2003, 654 (1-3) : 253 - 262
  • [49] Tests of Association for Quantitative Traits in Nuclear Families Using Principal Components to Correct for Population Stratification
    Zhang, Lei
    Li, Jian
    Pei, Yu-Fang
    Liu, Yongjun
    Deng, Hong-Wen
    [J]. ANNALS OF HUMAN GENETICS, 2009, 73 : 601 - 613
  • [50] Linear mixed models for association analysis of quantitative traits with next-generation sequencing data
    Chiu, Chi-yang
    Yuan, Fang
    Zhang, Bingsong
    Yuan, Ao
    Li, Xin
    Fang, Hong-Bin
    Lange, Kenneth
    Weeks, Daniel E.
    Wilson, Alexander F.
    Bailey-Wilson, Joan E.
    Musolf, Anthony M.
    Stambolian, Dwight
    Lakhal-Chaieb, M'Hamed Lajmi
    Cook, Richard J.
    McMahon, Francis J.
    Amos, Christopher I.
    Xiong, Momiao
    Fan, Ruzong
    [J]. GENETIC EPIDEMIOLOGY, 2019, 43 (02) : 189 - 206
12345