Score tests for epistasis models on quantitative traits using general pedigree data

被引：4
|
作者：
Wang, K [1 ]
机构：
[1] Univ Iowa, Coll Publ Hlth, Dept Biostat, Div Stat Genet, Iowa City, IA 52242 USA
来源：
GENETIC EPIDEMIOLOGY | 2003年 / 25卷 / 04期
关键词：
QTL; epistasis; variance component; likelihood ratio statistic; score statistic;
D O I：
10.1002/gepi.10266
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Efficient score tests for a two-locus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalency to their respective likelihood ratio tests and efficiency in computation. The finite-sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：314 / 326
页数：13
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