Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and β-amino acid derivatives

被引：2

作者：

Gundogdu, Ozlem ^{[1
]}

Turhan, Pinar ^{[1
]}

Kose, Aytekin ^{[1
]}

Altundas, Ramazan ^{[1
]}

Kara, Yunus ^{[1
]}

机构：

[1] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey

来源：

TETRAHEDRON-ASYMMETRY | 2017年 / 28卷 / 09期

关键词：

ASPARTIC-ACID; MECHANISM;

D O I：

10.1016/j.tetasy.2017.08.009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The ring-opening reaction of homoserine lactone with phenylmagnesium bromides was systematically examined. A reliable method to achieve beta-amino acid precursors was developed by tuning the reaction conditions to favor mono-addition to the carbonyl moiety of the lactone. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1163 / 1168

页数：6

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