Rose bengal photocatalyzed Knoevenagel condensation of aldehydes and ketones in aqueous medium

被引：27
|
作者：
Das, Anupam [1 ]
Thomas, K. R. Justin [1 ]
机构：
[1] Indian Inst Technol Roorkee, Dept Chem, Organ Mat Lab, Roorkee 247667, Uttar Pradesh, India
来源：
GREEN CHEMISTRY | 2022年 / 24卷 / 12期
关键词：
EFFICIENT ROUTE; CATALYST-FREE; ONE-POT; OXIDATION; INDOLES; ACCESS; AMINES; GREEN; WATER;
D O I：
10.1039/d2gc01402e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Knoevenagel condensation is widely used in organic synthetic chemistry and several reaction conditions have been demonstrated. These reactions in neutral medium are challenging. In this report, we present a sustainable and greener method for Knoevenagel condensation reaction between carbonyl compounds (both aldehydes and ketones) and active methylene compounds using rose bengal as a photosensitizer in an aqueous medium. This protocol works smoothly for aromatic aldehydes and ketones containing both electron-donating and electron-withdrawing substituents.
引用
收藏
页码：4952 / 4957
页数：6
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