Synthesis and Antiviral Activity of Glycyrrhizic-Acid Conjugates with Aromatic Amino Acids

被引：7
|
作者：
Baltina, L. A., Jr. [1 ]
Fairushina, A. I. [1 ]
Baltina, L. A. [1 ]
Eropkin, M. Yu. [2 ]
Konovalova, N. I. [2 ]
Petrova, P. A. [2 ]
Eropkina, E. M. [2 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, 71 Prosp Oktyabrya, Ufa 450054, Russia
[2] Minist Healthcare RF, Res Inst Influenza, 15-17 Prof Popova St, St Petersburg 1987376, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 06期
关键词：
glycyrrhizic acid; conjugates; amino acids; synthesis; antiviral activity; DERIVATIVES;
D O I：
10.1007/s10600-017-2209-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Amino-acid conjugates of glycyrrhizic acid (GA) containing phenylalanine, tyrosine, and tryptophan in the carbohydrate and triterpene parts were synthesized using N-hydroxybenzotriazole (HOBt)-N,N'-dicyclohexylcarbodiimide (DCC) and sodium salts of the amino acids. GA conjugates containing two aminoacid residues in the glycoside carbohydrate part were synthesized using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The GA conjugate with tyrosine exhibited weak but consistent antiviral activity against flu virus A/St.-Petersburg/05/09 (H1N1)pdm09 that was similar to the standard strain A/California/07/09 and pronounced antiviral activity against respiratory-syncytial virus (RSV) and herpes simplex virus (HSV-1).
引用
收藏
页码：1096 / 1100
页数：5
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