In Situ Generation of Quinolinium Ylides from Diazo Compounds: Copper-Catalyzed Synthesis of Indolizine

被引：54

作者：

Chen, Rongxiang ^{[1
]}

Zhao, Yanwei ^{[1
]}

Sun, Hongmei ^{[1
]}

Shao, Ying ^{[1
,2
]}

Xu, Yudong ^{[1
]}

Ma, Meihua ^{[1
]}

Ma, Liang ^{[1
]}

Wan, Xiaobing ^{[1
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Changzhou Univ, Jiangsu Key Lab Adv Catalyt Mat & Technol, Adv Catalysis & Green Mfg Collaborat Innovat Ctr, Changzhou 213164, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 18期

基金：

中国博士后科学基金;

关键词：

ONE-POT SYNTHESIS; ALPHA-DIAZOCARBONYL COMPOUNDS; PYRIDINIUM YLIDES; 1,3-DIPOLAR CYCLOADDITION; QUINOLIZIDINE ALKALOIDS; N-YLIDES; FUNCTIONALIZED INDOLIZINES; TRANSANNULATION REACTION; SUBSTITUTED INDOLIZINES; OXIDATIVE ANNULATION;

D O I：

10.1021/acs.joc.7b01042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides. This methodology is distinguished by the use of a commercially inexpensive catalyst and readily available starting materials, wide substrate scope, and operational simplicity.

引用

页码：9291 / 9304

页数：14

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