Restless Legs Syndrome and Parkinson's Disease in Men

被引：34

作者：

Gao, Xiang ^{[1
,2
,3
]}

Schwarzschild, Michael A. ^{[4
]}

O'Reilly, Eilis J. ^{[3
,5
]}

Wang, Hao ^{[3
]}

Ascherio, Alberto ^{[1
,2
,3
,5
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 15期

关键词：

restless legs syndrome; Parkinson's disease; men; CORONARY-HEART-DISEASE; PHOBIC ANXIETY; RISK; DIAGNOSIS; WOMEN; PATHOPHYSIOLOGY; PREVALENCE; QUALITY;

D O I：

10.1002/mds.23256

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined whether men with restless legs syndrome (RLS) have a higher prevalence of Parkinson's disease (PD) among 23,119 US participants of the Health Professional Follow-up Study who were free of diabetes and arthritis. RLS was assessed using a set of standardized questions recommended by the International RLS Study Group. PD cases were identified by self-reported questionnaires and confirmed by review of medical records. Compared to men without RLS, multivariate-adjusted odds ratios for PD were 1.1 (95% confidence interval: 0.4, 3.0) for men with RLS symptoms 5-14 times per month and 3.09 (95% confidence interval: 1.5, 6.2; P trend = 0.003) for those with symptoms 15 times or more per month, after adjusting for age, smoking, use of antidepressant, and other covariates. In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD. (C) 2010 Movement Disorder Society

引用

页码：2654 / 2657

页数：4

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