Synthesis of Macrolides with Hydrazide Fragments from Tetrahydropyran and 2,6-Pyridinedicarboxylic Acid

被引：5
|
作者：
Ishmuratov, Gumer Yu. [1 ]
Yakovleva, Marina P. [1 ]
Shutova, Mariya A. [1 ]
Yaubasarov, Niyaz R. [1 ]
Muslukhov, Rinat R. [1 ]
Viripaev, Evgeny M. [1 ]
Tolstikov, Alexander G. [1 ]
机构：
[1] RAS, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Russia
来源：
MACROHETEROCYCLES | 2014年 / 7卷 / 03期
关键词：
Tetrahydropyran; macrolides with dihydrazide fragments; 1+1]-condensation; synthesis; DERIVATIVES; ESTER;
D O I：
10.6060/mhc140374y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of two potentially useful 23- and 29-membered macrolides containing a pyridine ring and dihydrazide fragments was developed starting from tetrahydropyran. It was based on [1+1]-condensation of 7'-oxooctyl-7-oxooctanoate and bis(7-oxooctyl) hexanedioate with 2,6-pyridinedicarboxylic acid hydrazide. The structure of the macrocycles obtained was confirmed using by IR and NMR spectroscopy and mass spectrometry.
引用
收藏
页码：721 / 724
页数：4
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