Pyrola incarnata demonstrates neuroprotective effects against β-amyloid-induced memory impairment in mice

被引:5
|
作者
Li, Shuang-Jun [1 ]
Liu, Qian [1 ]
He, Xiao-Bin [2 ]
Liu, Jin-Ping [1 ]
Liu, Xiao-Liu [1 ]
Hu, Jie [1 ]
Tang, Zhi-Peng [1 ]
Peng, Qing-Yun [1 ]
Cui, Lian-Jie [1 ]
Zhang, Hua-Ni [3 ]
Yang, Xi-Liang [1 ]
Wang, Qiang [1 ]
Zhang, Zhi-Jian [2 ]
机构
[1] Wuhan Univ Sci & Technol, Dept Pharm, Hubei Prov Key Lab Occupat Hazard Identificat & C, Inst Infect Immunol & Tumor Microenvironm,Med Col, Wuhan 430081, Hubei, Peoples R China
[2] Chinese Acad Sci, Ctr Brain Sci,Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan Ctr Magnet Resonance,Key Lab Magnet Resonan, Wuhan 430071, Hubei, Peoples R China
[3] Shiyan Hosp Integrated Tradit & Western Med, Dept Pharm, Shiyan 442000, Hubei, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
A beta(25)(-35); Microglia; Neurodegenerative; Pyrola incarnata; Ursolic acid; ANTIOXIDANT ACTIVITY; PLAQUE-FORMATION; OLEANOLIC ACID; CORNI-FRUCTUS; URSOLIC ACID; BRAIN; ACCUMULATION; MICROGLIA; INJECTION; EXTRACT;
D O I
10.1016/j.bmcl.2019.126858
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This study aims to investigate the neuroprotective effects of Pyrola incarnata against beta-amyloid-induced memory impairment in mice. Ethanol extract of Pyrola incarnata (EPI) was obtained and led to eleven phytochemicals successfully by isolation and purification, which were elucidated by spectroscopic analysis (H-1 NMR, C-13 NMR and HR-ESI-MS). Thereinto, ursolic acid was gained as most abundant monomer. C57BL/6 mice were intracerebroventricular injected with aggregated A beta(25-35). Open-field test, Barnes maze test and Morris water maze were conducted for evaluating cognition processes of EPI and ursolic acid. EPI significantly improved learning and memory deficits, attenuated the A beta(25-35) level of deposition immunohistochemically. Further studies revealed that ursolic acid as bioactive phytochemical of P. incarnata improved spatial memory performance and ameliorated A beta(25-35 )accumulation by activating microglia cells and up-regulating Ibal level in the hippocampus. These findings suggest P. incarnata could improve the cognition of mice and be a promising natural source for the treatment of neurodegenerative disease.
引用
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页数:10
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