Synthesis and evaluation of 17-alpha-heteroarylvinyl estradiols as ligands for the estrogen receptor ligand binding domain (ER-LBD)

被引:0
|
作者
Olmsted, Sandra [1 ]
Hanson, Robert N. [2 ]
Tongcharoensirikul, Pakamas [2 ]
McCaskill, Emmett [2 ]
Hochberg, Richard B. [3 ]
Labaree, David C. [3 ]
机构
[1] Augsburg Coll, Dept Chem, Minneapolis, MN 55454 USA
[2] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA
[3] Yale Univ, Sch Med, Dept Obstet & Gynecol, New Haven, CT 06510 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
373-MEDI
引用
收藏
页码:711 / 711
页数:1
相关论文
共 50 条
  • [41] EXPRESSION OF THE LIGAND-BINDING DOMAIN-CONTAINING REGION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA IN ESCHERICHIA-COLI AND EVALUATION OF LIGAND-BINDING SELECTIVITY
    FUKASAWA, H
    IIJIMA, T
    KAGECHIKA, H
    HASHIMOTO, Y
    SHUDO, K
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1993, 16 (04) : 343 - 348
  • [43] Small-angle X-ray scattering studies on structures of an estrogen-related receptor α ligand binding domain and its complexes with ligands and coactivators
    Jin, Kyeong Sik
    Park, Joon Kyu
    Yoon, Jinhwan
    Rho, Yecheol
    Kim, Jae-Hong
    Kim, Eunice EunKyeong
    Ree, Moonhor
    JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (32): : 9603 - 9612
  • [44] Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor α (hERα) LBD:: quantitative structure-activity relationships within a series of CYP3A4 inducers where induction is mediated via hGR involvement
    Lewis, DFV
    Ogg, MS
    Goldfarb, PS
    Gibson, GG
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 82 (2-3): : 195 - 199
  • [45] Synthesis and evaluation of isomeric (17α,20E)-11β-methoxy-21-(trifluoromethylphenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as ERα-Hormone binding domain ligands:: Effect of the methoxy group on receptor binding and uterotrophic growth
    Hanson, Robert N.
    Tongcharoensirikul, Pakamas
    Dilis, Robert
    Hughes, Alun
    DeSombre, Eugene R.
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (03) : 472 - 479
  • [46] Molecular basis of agonistic activity of ERα7p, a synthetic peptide corresponding to a sequence located at the N-terminal part of the estrogen receptor α ligand binding domain
    Gallo, Dominique
    Jacquot, Yves
    Cleeren, Anny
    Jacquemotte, Francoise
    Laios, Ioanna
    Laurent, Guy
    Leclercq, Guy
    LETTERS IN DRUG DESIGN & DISCOVERY, 2007, 4 (05) : 346 - 355
  • [47] Freeze-Frame Click-Chemistry Synthesis on a Soluble Alpha-7 Nicotinic Acetylcholine Receptor (nAChR) Ligand Binding Domain
    Nemecz, Akos
    Talley, Todd
    Fotsing, Joseph
    Weide, Timo
    Grimster, Neil
    Ho, Kwok-Yiu
    Fokin, Valery V.
    Sharpless, K. Barry
    Taylor, Palmer
    FASEB JOURNAL, 2008, 22
  • [48] PROGESTIN 16-ALPHA, 17-ALPHA-DIOXOLANE KETALS AS MOLECULAR PROBES FOR THE PROGESTERONE-RECEPTOR - SYNTHESIS, BINDING-AFFINITY, AND PHOTOCHEMICAL EVALUATION
    KYM, PR
    CARLSON, KE
    KATZENELLENBOGEN, JA
    JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (09) : 1111 - 1119
  • [49] Synthesis and evaluation of (17α,20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as ligands for the estrogen receptor α hormone binding domain:: Comparison with 20E-isomers
    Hanson, RN
    Friel, CJ
    Dilis, R
    Hughes, A
    DeSombre, ER
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) : 4300 - 4311
  • [50] Homology models of mouse and rat estrogen receptor-α ligand-binding domain created by in silico mutagenesis of a human template: Molecular docking with 17β-estradiol, diethylstilbestrol, and paraben analogs
    Gonzalez T.L.
    Rae J.M.
    Colacino J.A.
    Richardson R.J.
    Computational Toxicology, 2019, 10 : 1 - 16