CARs need a jump start to get going

被引：0
|
作者：
Lillemeier, Bjorn F. [1 ,2 ]
机构：
[1] Salk Inst Biol Studies, Nomis Ctr Immunobiol & Microbial Pathogenesis, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[2] Salk Inst Biol Studies, Waitt Adv Biophoton Ctr, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
NATURE IMMUNOLOGY | 2020年 / 21卷 / 08期
关键词：
CHIMERIC ANTIGEN RECEPTORS; T-CELLS; DOMAIN;
D O I：
10.1038/s41590-020-0735-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.
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页码：823 / 824
页数：2
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