Xenobiotic metabolizing and transporter genes: gene-gene interactions in schizophrenia and related disorders

被引：0
|
作者：
Gasso, Patricia [1 ,2 ]
Mas, Sergi [1 ,2 ]
Alvarez, Santi [1 ,2 ]
Trias, Gemma [1 ]
Bioque, Miquel [2 ,3 ]
Oliveira, Cristina [2 ,3 ]
Bernardo, Miquel [2 ,3 ,4 ]
Lafuente, Amalia [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Anat Pathol Pharmacol & Microbiol, E-08036 Barcelona, Spain
[2] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
[3] Hosp Clin Barcelona, Psychiat Serv, E-08036 Barcelona, Spain
[4] Univ Barcelona, Dept Psychiat & Clin Psychobiol, E-08036 Barcelona, Spain
来源：
PHARMACOGENOMICS | 2010年 / 11卷 / 12期
关键词：
ABCB1; CYP1A2; CYP2D6; CYP3A5; epistasis; pharmacogenetics; schizophrenia; ASSOCIATION; PERSONALITY; POLYMORPHISM; BRAIN; EXPRESSION; GENOTYPE; MDR1; SUSCEPTIBILITY; POPULATION; EPISTASIS;
D O I：
10.2217/PGS.10.158
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aims: In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders. Materials & methods: A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study. We analyzed gene gene interactions by multifactor dimensionality reduction. Results: A four-way model including ABCB1 G2677T, CYP3A5*3, CYP1A2*1F and CYP2D6*4 variants had the best overall performances (accuracy: 0.573) and a crossvalidation consistency of 10/10 (permutation testing p < 0.004). Conclusion: Our results suggest a significant involvement of CYPs and transporters in brain metabolism and homeostasis, and provide evidence of gene gene interactions among xenobiotic metabolizing and transporter genes in the context of schizophrenia.
引用
收藏
页码：1725 / 1731
页数：7
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