Rho GTPases as therapeutic targets in cancer and other human diseases

被引：0
|
作者：
Lorenzano Menna, Pablo [1 ]
Cardama, Georgina A. [1 ]
Comin, Maria J. [2 ]
Alonso, Daniel F. [1 ]
Gomez, Daniel E. [1 ]
机构：
[1] Univ Nacl Quilmes, Oncol Mol Lab, Dept Ciencia & Tecnol, RA-1876 Buenos Aires, DF, Argentina
[2] INTI, Ctr Invest & Desarrollo Quim, Buenos Aires, DF, Argentina
来源：
MEDICINA-BUENOS AIRES | 2010年 / 70卷 / 06期
关键词：
cell signaling; cytoskeleton; cell migration; neurodegenerative diseases; cancer; PROTEIN-KINASE-C; MAMMARY-CARCINOMA CELLS; GDP EXCHANGE FACTOR; ANTIESTROGEN RESISTANCE; BREAST-CANCER; RAC3; GTPASES; ACTIVATION; RAS; TIAM1; INHIBITORS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rho GTPases as therapeutic targets in cancer and other human diseases. Rho GTPases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases. The aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. We also address the role of Rho GTPases in the development of different human diseases such as cancer. Finally, we describe different experimental therapeutic strategies with Rho GTPases as molecular targets.
引用
收藏
页码：555 / 564
页数：10
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